Specific Recognition of Cruciform DNA by Nuclear Protein HMG1
- 24 February 1989
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 243 (4894), 1056-1059
- https://doi.org/10.1126/science.2922595
Abstract
Cruciform DNA, a non-double helix form of DNA, can be generated as an intermediate in genetic recombination as well as from palindromic sequences under the effect of supercoiling. Eukaryotic cells are equipped with a DNA-binding protein that selectively recognizes cruciform DNA. Biochemical and immunological data showed that this protein is HMG1, an evolutionarily conserved, essential, and abundant component of the nucleus. The interaction with a ubiquitous protein points to a critical role for cruciform DNA conformations.Keywords
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