Blood lipids and human coronary atherosclerosis regression: the angiographic evidence

Abstract

Five angiographic trials are reviewed. Together, their reports clearly confirm that aggressive blood lipid-lowering therapy can reduce progression of human coronary atherosclerosis and produce regression in some subjects. The degree of change observed in lesions with lipid lowering is small compared with what can be accomplished by interventional cardiologists, but compatible with reversal of spontaneous growth rates as estimated from autopsy surveys.