Pharmacometabolomics: Implications for Clinical Pharmacology and Systems Pharmacology
- 5 November 2013
- journal article
- review article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 95 (2), 154-167
- https://doi.org/10.1038/clpt.2013.217
Abstract
Metabolomics, the study of metabolism at an "omic" level, has the potential to transform our understanding of mechanisms of drug action and the molecular basis for variation in drug response. It is now possible to define metabolic signatures of drug exposure that can identify pathways involved in both drug efficacy and adverse drug reactions. In addition, the "metabotype," the metabolic "signature" of a patient, is a unique identity that contains information about drug response and disease heterogeneity. The application of metabolomics for the study of drug effects and variation in drug response is creating "pharmacometabolomics," a discipline that will contribute to personalized drug therapy and will complement pharmacogenomics by capturing environmental and microbiome-level influences on response to drug therapy. This field has the potential to transform pharmacology and clinical pharmacology in significant ways and will contribute to efforts for personalized therapy. This overview highlights developments in the new discipline of pharmacometabolomics.Keywords
This publication has 75 references indexed in Scilit:
- Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole PathwayPLOS ONE, 2013
- Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placeboTranslational Psychiatry, 2013
- Metabolomics Reveals Amino Acids Contribute to Variation in Response to Simvastatin TreatmentPLOS ONE, 2012
- Acute Mesenteric Infarction Associated with Atrial FibrillationThe New England Journal of Medicine, 2011
- Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics StudyMetabolomics, 2010
- Metabolomics: A Global Biochemical Approach to Drug Response and DiseaseAnnual Review of Pharmacology and Toxicology, 2008
- Pharmacogenetics and Pharmacogenomics: Development, Science, and TranslationAnnual Review of Genomics and Human Genetics, 2006
- Pharmacogenomics: bench to bedsideNature Reviews Drug Discovery, 2004
- Genetic control of dicumarol levels in manJCI Insight, 1968
- Genetic Control of Drug Levels in Man: AntipyrineScience, 1968