Increased levels of pigment epithelium-derived factor in aqueous humor of patients with uveitis
- 1 February 2007
- journal article
- research article
- Published by BMJ in British Journal of Ophthalmology
- Vol. 91 (2), 149-150
- https://doi.org/10.1136/bjo.2006.103804
Abstract
Aim: To evaluate whether aqueous humor levels of pigment epithelium-derived factor (PEDF) are increased in patients with uveitis Methods: Aqueous humor levels of PEDF and tumour necrosis factor α (TNFα) were determined by ELISA in 34 uveitis samples and 9 cataract control samples. Results: Aqueous humor PEDF and TNFα levels were significantly higher in patients with uveitis than in controls (mean (SD) 6.4 (0.8) v 1.3 (0.2) μg/ml and 14.7 (3.8) v 4.2 (0.4) pg/ml, respectively; pConclusion: The results show that aqueous humor levels of PEDF are increased in patients with uveitis. Our observations suggest that aqueous humor levels of PEDF may be increased as a countersystem against inflammation in uveitis.Keywords
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