Transcriptomic Studies of the Airway Field of Injury Associated with Smoking-Related Lung Disease
- 1 May 2011
- journal article
- Published by American Thoracic Society in Proceedings of the American Thoracic Society
- Vol. 8 (2), 173-179
- https://doi.org/10.1513/pats.201011-066ms
Abstract
The “field of injury” hypothesis proposes that exposure to an inhaled insult such as cigarette smoke elicits a common molecular response throughout the respiratory tract. This response can therefore be quantified in any airway tissue, including readily accessible epithelial cells in the bronchus, nose, and mouth. High-throughput technologies, such as whole-genome gene expression microarrays, can be employed to catalog the physiological consequences of such exposures in the airway epithelium. Pulmonary diseases such as chronic obstructive pulmonary disease, lung cancer, and asthma are also thought to be associated with a field of injury, and in patients with these diseases, airway epithelial cells can be a useful surrogate for diseased tissue that is often difficult to obtain. Global measurement of mRNA and microRNA expression in these cells can provide useful information about the molecular pathogenesis of such diseases and may be useful for diagnosis and for predicting prognosis and response to therapy. ...Keywords
This publication has 51 references indexed in Scilit:
- T helper Type 2 Differentiation is Associated with Induction of Antibacterial Defense Mechanisms in Blood Lymphocytes of Patients with SarcoidosisImmunological Investigations, 2009
- A Genome-Wide Expression Analysis in Blood Identifies Pre-Elafin as a Biomarker in ARDSAmerican Journal of Respiratory Cell and Molecular Biology, 2008
- Gene Expression Profiling in Patients with Chronic Obstructive Pulmonary Disease and Lung CancerAmerican Journal of Respiratory and Critical Care Medicine, 2008
- Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroidsProceedings of the National Academy of Sciences of the United States of America, 2007
- Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancerNature Medicine, 2007
- Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expressionGenome Biology, 2007
- Effect of active smoking on the human bronchial epithelium transcriptomeBMC Genomics, 2007
- Cigarette smoke-induced differential gene expression in blood cells from monozygotic twin pairsCarcinogenesis: Integrative Cancer Research, 2006
- Progressive pulmonary sarcoidosis is associated with over-expression of TYK2 and p21Waf1/Cip1.2006
- Gene Expression Profiling of Human Lung Tissue from Smokers with Severe EmphysemaAmerican Journal of Respiratory Cell and Molecular Biology, 2004