Insights into RNA structure and function from genome-wide studies
Top Cited Papers
- 13 May 2014
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Genetics
- Vol. 15 (7), 469-479
- https://doi.org/10.1038/nrg3681
Abstract
A comprehensive understanding of RNA structure will provide fundamental insights into the cellular function of both coding and non-coding RNAs. Although many RNA structures have been analysed by traditional biophysical and biochemical methods, the low-throughput nature of these approaches has prevented investigation of the vast majority of cellular transcripts. Triggered by advances in sequencing technology, genome-wide approaches for probing the transcriptome are beginning to reveal how RNA structure affects each step of protein expression and RNA stability. In this Review, we discuss the emerging relationships between RNA structure and the regulation of gene expression.Keywords
This publication has 106 references indexed in Scilit:
- Rate-Limiting Steps in Yeast Protein TranslationCell, 2013
- RNA structure and the mechanisms of alternative splicingCurrent Opinion in Genetics & Development, 2011
- Free State Conformational Sampling of the SAM-I Riboswitch Aptamer DomainStructure, 2010
- Advances in RNA structure analysis by chemical probingCurrent Opinion in Structural Biology, 2010
- Role of RNA structure in regulating pre-mRNA splicingTrends in Biochemical Sciences, 2009
- mRNA Localization: Gene Expression in the Spatial DimensionCell, 2009
- MicroRNAs: Target Recognition and Regulatory FunctionsCell, 2009
- A Link between RNA Metabolism and Silencing Affecting Arabidopsis DevelopmentDevelopmental Cell, 2008
- Endogenous siRNA and miRNA Targets Identified by Sequencing of the Arabidopsis DegradomeCurrent Biology, 2008
- The response of mammalian cells to double-stranded RNACytokine & Growth Factor Reviews, 2007