Ready‐to‐use introduction schedules for first exposure to allergenic foods in children at home
- 28 June 2008
- Vol. 63 (7), 903-909
- https://doi.org/10.1111/j.1398-9995.2008.01634.x
Abstract
Background: The vast majority of children will undergo their first exposure to common allergenic foods at home. However, the first exposure may lead to clinical reactions. It has been proposed to introduce allergenic foods gradually into the diets of children at risk for food allergy, but no practical dietary advice has been devised. Objective: The aim of this study was to devise safe introduction schedules for common allergenic foods for use at home, based on the challenge doses as administered in double‐blind, placebo‐controlled food challenge (DBPCFCs) in children who were never exposed previously to these foods. Methods: Seventy‐two DBPCFCs were performed in 63 children as a first known exposure. The incrementing challenge doses were converted into equivalent portions of these foods in their usual household form and incorporated in introduction schedules. The feasibility of the introduction scales was tested in parents of the children attending our clinic. Results: Based on the results of the positive challenges (37) in which severe reactions did not occur, detailed introduction schedules and a reference photograph of the required increasing amounts of food were devised for use at home. Feasibility testing showed that, when using these introduction schedules, parents portioned the initial doses significantly lower than without detailed instructions. Conclusions: The introduction schedules and reference photograph provide information for parents to introduce the required amounts of allergenic foods in initial low doses at home. This is expected to improve the safety of this procedure.Keywords
This publication has 17 references indexed in Scilit:
- Placebo reactions in double‐blind, placebo‐controlled food challenges in childrenAllergy, 2007
- The management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunologyAllergy, 2007
- Dietary assessment in children adhering to a food allergen avoidance diet for allergy preventionEuropean Journal of Clinical Nutrition, 2006
- Food allergy and the introduction of solid foods to infants: a consensus documentAnnals of Allergy, Asthma & Immunology, 2006
- Maternal experiences of peanut avoidance during pregnancy/lactation: An in‐depth qualitative studyPediatric Allergy and Immunology, 2005
- Does severity of low‐dose, double‐blind, placebo‐controlled food challenges reflect severity of allergic reactions to peanut in the community?Clinical and Experimental Allergy, 2005
- The predictive value of a positive prick skin test to peanut in atopic, peanut-naïve childrenAnnals of Allergy, Asthma & Immunology, 2003
- Utility of food-specific IgE concentrations in predicting symptomatic food allergyJournal of Allergy and Clinical Immunology, 2001
- Relationship between oral challenges with previously uningested egg and egg-specific IgE antibodies and skin prick tests in infants with food allergyJournal of Allergy and Clinical Immunology, 1995
- Quantitative skin prick testingAllergy, 1987