Ca2+ sensors of L‐type Ca2+ channel
- 29 December 2000
- journal article
- Published by Wiley in FEBS Letters
- Vol. 487 (2), 301-306
- https://doi.org/10.1016/s0014-5793(00)02361-9
Abstract
Ca2+-induced inactivation of L-type Ca2+ is differentially mediated by two C-terminal motifs of the α1C subunit, L (1572–1587) and K (1599–1651) implicated for calmodulin binding. We found that motif L is composed of a highly selective Ca2+ sensor and an adjacent Ca2+-independent tethering site for calmodulin. The Ca2+ sensor contributes to higher Ca2+ sensitivity of the motif L complex with calmodulin. Since only combined mutation of both sites removes Ca2+-dependent current decay, the two-site modulation by Ca2+ and calmodulin may underlie Ca2+-induced inactivation of the channelKeywords
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