MOLECULAR BIOLOGY OF ODORANT RECEPTORS IN VERTEBRATES
- 1 March 1999
- journal article
- review article
- Published by Annual Reviews in Annual Review of Neuroscience
- Vol. 22 (1), 487-509
- https://doi.org/10.1146/annurev.neuro.22.1.487
Abstract
▪ Abstract The initial step in olfactory discrimination involves the interaction of odorous ligands with specific receptors on the surface of olfactory sensory neurons. The foundation for a molecular understanding of odor recognition in vertebrates was provided by the identification of a family of genes encoding putative odorant receptors, by Buck & Axel in 1991 . Odorant receptor (OR) genes form the largest gene family in the vertebrate genome. This review summarizes progress over the past seven years. Major new insights are: Olfaction is accomplished in vertebrates by a very large number of receptors; olfactory sensory neurons express a small subset of the OR repertoire; in rat and mouse, axons of neurons expressing the same OR converge onto defined glomeruli in the olfactory bulb.Keywords
This publication has 82 references indexed in Scilit:
- Isolation of putative olfactory receptor sequences from pig nasal epitheliumNeuroscience Letters, 1998
- A first map of the porcine major histocompatibility complex class I regionTissue Antigens, 1998
- Molecular Cloning and Chromosomal Mapping of Olfactory Receptor Genes Expressed in the Male Germ Line: Evidence for Their Wide Distribution in the Human GenomeBiochemical and Biophysical Research Communications, 1997
- Visualizing an Olfactory Sensory MapCell, 1996
- Laminar segregation of odorant receptor expression in the olfactory epitheliumCell and tissue research, 1996
- Genomic Structure and Transcription of a Murine Odorant Receptor Gene: Differential Initiation of Transcription in the Olfactory and Testicular CellsBiochemical and Biophysical Research Communications, 1996
- The chromosomal distribution of mouse odorant receptor genes.Proceedings of the National Academy of Sciences of the United States of America, 1996
- Allelic inactivation regulates olfactory receptor gene expressionCell, 1994
- The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13→p12 region of the human genome and reveals an MspI restriction fragment length polymorphismCytogenetic and Genome Research, 1993
- A novel multigene family may encode odorant receptors: A molecular basis for odor recognitionCell, 1991