Fungal Pigments and Their Roles Associated with Human Health
Open Access
- 12 November 2020
- journal article
- review article
- Published by MDPI AG in Journal of Fungi
- Vol. 6 (4), 280
- https://doi.org/10.3390/jof6040280
Abstract
Fungi can produce myriad secondary metabolites, including pigments. Some of these pigments play a positive role in human welfare while others are detrimental. This paper reviews the types and biosynthesis of fungal pigments, their relevance to human health, including their interactions with host immunity, and recent progresses in their structure–activity relationships. Fungal pigments are grouped into carotenoids, melanin, polyketides, and azaphilones, etc. These pigments are phylogenetically broadly distributed. While the biosynthetic pathways for some fungal pigments are known, the majority remain to be elucidated. Understanding the genes and metabolic pathways involved in fungal pigment synthesis is essential to genetically manipulate the production of both the types and quantities of specific pigments. A variety of fungal pigments have shown wide-spectrum biological activities, including promising pharmacophores/lead molecules to be developed into health-promoting drugs to treat cancers, cardiovascular disorders, infectious diseases, Alzheimer’s diseases, and so on. In addition, the mechanistic elucidation of the interaction of fungal pigments with the host immune system provides valuable clues for fighting fungal infections. The great potential of fungal pigments have opened the avenues for academia and industries ranging from fundamental biology to pharmaceutical development, shedding light on our endeavors for disease prevention and treatment.Keywords
This publication has 210 references indexed in Scilit:
- Helicusin E, Isochromophilone X and Isochromophilone XI: New Chloroazaphilones Produced by the Fungus Bartalinia robillardoides Strain LF550Marine Drugs, 2013
- Inhibition of Tumor Cells Interacting with Stromal Cells by Xanthones Isolated from a Costa Rican Penicillium sp.Journal of Natural Products, 2012
- Melanin Externalization in Candida albicans Depends on Cell Wall Chitin StructuresEukaryotic Cell, 2010
- Melanin in Fonsecaea pedrosoi: a trap for oxidative radicalsBMC Microbiology, 2010
- Perylenequinone Natural Products: Total Synthesis of Hypocrellin AThe Journal of Organic Chemistry, 2009
- Activation of antibacterial autophagy by NADPH oxidasesProceedings of the National Academy of Sciences of the United States of America, 2009
- Novel expression hosts for complex secondary metabolite megasynthetases: Production of myxochromide in the thermopilic isolate Corallococcus macrosporus GT-2Microbial Cell Factories, 2009
- Retinal Biosynthesis in Fungi: Characterization of the Carotenoid Oxygenase CarX fromFusarium fujikuroiEukaryotic Cell, 2007
- Is there a role for antioxidant carotenoids in limiting self-harming immune response in invertebrates?Biology Letters, 2007
- Search for Cell Motility and Angiogenesis Inhibitors with Potential Anticancer Activity: Beauvericin and Other Constituents of Two Endophytic Strains of Fusarium oxysporumJournal of Natural Products, 2007