Inflammation, atherosclerosis, and arterial thrombosis: Role of the scavenger receptor CD36
- 1 February 2009
- journal article
- review article
- Published by Cleveland Clinic Journal of Medicine in Cleveland Clinic Journal of Medicine
- Vol. 76 (4 uppl 2), S27-S30
- https://doi.org/10.3949/ccjm.76.s2.06
Abstract
The CD36 scavenger receptor recognizes oxidized low-density lipoprotein (LDL) and cell-derived microparticles. It is expressed on macrophages and platelets and is a mediator of both atherogenesis and thrombosis. Macrophages from CD36-null mice have a defect in foam cell formation in response to exposure to oxidized LDL, and CD36-null mice fed an atherogenic Western diet have significantly less atherosclerosis than their wild-type counterparts. On platelets, CD36 recognition of oxidized LDL contributes to their activation and provides a mechanistic link between hyperlipidemia, oxidant stress, and the prothrombotic state. Cell-derived microparticles are also major ligands for CD36 and contribute to thrombus formation in a CD36-dependent manner even in the absence of hyperlipidemia. CD36 deficiency in mice is associated with inhibition of thrombus formation and with a reduction in microparticle accumulation in thrombi. Targeting CD36 is a promising avenue for the treatment of atheroinflammatory disorders.Keywords
This publication has 12 references indexed in Scilit:
- A Specific CD36-Dependent Signaling Pathway Is Required for Platelet Activation by Oxidized Low-Density LipoproteinCirculation Research, 2008
- Platelet CD36 mediates interactions with endothelial cell–derived microparticles and contributes to thrombosis in miceJCI Insight, 2008
- Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotypeNature Medicine, 2007
- Oxidized phosphatidylserine–CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cellsThe Journal of Experimental Medicine, 2006
- A CD36-dependent signaling cascade is necessary for macrophage foam cell formationCell Metabolism, 2006
- Stem Cell Transplantation Reveals That Absence of Macrophage CD36 Is Protective Against AtherosclerosisArteriosclerosis, Thrombosis, and Vascular Biology, 2004
- CD36 and atherosclerosisCurrent Opinion in Lipidology, 2000
- Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in miceJCI Insight, 2000
- PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDLCell, 1998
- Lewis A. Conner Memorial LectureCirculation, 1997