Acute nonlymphocytic leukemia in 171 children
- 1 January 1976
- journal article
- research article
- Published by Wiley in Medical and Pediatric Oncology
- Vol. 2 (2), 119-146
- https://doi.org/10.1002/mpo.2950020203
Abstract
The initial features, response to therapy, complications, cause of death, and prognostic factors of 171 consecutive children with ANLL are described and compared to historical data for adults with ANLL and for children with ALL. Major differences between children and adults with ANLL include a higher frequency of CNS leukemia and a lower frequency of early deaths in the children. The most important differences between children with ANLL and ALL are the absence of a peak age of incidence in ANLL and the far better response to therapy in ALL. Among features present at 100,000/mm3 or above, and no palpable hepatomegaly had significantly longer survivals, while patients with platelet counts below 10,000/mm3 had significantly shorter survivals. The frequency and duration of remission were significantly better with three protocols used since 1968 than previously. However, even with these protocols, the results were far from satisfactory, with a complete remission frequency of 66%, a median duration of hematological remission of 6 months, and a median duration of survival of 10 months. The striking contrast of these results in childhood ANLL with current results in childhood ALL underscores the need for novel, imaginative therapeutic approaches for ANLL.Keywords
This publication has 43 references indexed in Scilit:
- Extramedullary involvement of the testes in childhood leukemiaCancer, 1975
- Splenectomy and chemotherapy in acute myelocytic leukemia of childhoodCancer, 1974
- The Therapy of Acute Granulocytic Leukemia in Patients More Than Fifty Years OldAnnals of Internal Medicine, 1974
- 6-azauridine in combination chemotherapy of childhood acute myelocytic leukemiaCancer, 1972
- Epidemiology of acute (and chronic) leukaemiasClinics in Haematology, 1972
- Epidemiological factors and survival experience in 1770 children with acute leukemia treated by members of children's study group a between 1957 and 1964Cancer, 1969
- Causes of Death in Acute LeukemiaJAMA, 1965
- Leukemia in ChildrenJAMA, 1964
- Meningeal leukemiaNeurology, 1960
- Simultaneous Occurrence of Mongolism and LeukemiaA.M.A. Journal of Diseases of Children, 1957