Cardiovascular effects of the South American medicinal plant Cecropia pachystachya (ambay) on rats
- 21 November 2004
- journal article
- research article
- Published by Elsevier BV in Journal of Ethnopharmacology
- Vol. 96 (3), 417-422
- https://doi.org/10.1016/j.jep.2004.09.030
Abstract
Cecropia pachystachya is used in South America for relieving cough and asthma. In Argentina it is known as “ambay” and grows in the neotropical forests (Ntr C.p.) and in temperate hilly regions (Tp C.p.). To evaluate their cardiovascular profile, the effect of extracts obtained from plants growing in the neotropical region as well as in temperate areas were compared by i.v. administration in normotensive rats. The following parameters were measured: blood pressure (BP) and heart rate (HR). The hypotensive effect was stronger for Ntr C.p., which aqueous extract decreased BP at doses between 90 and 300 mg lyophilised/kg until 46.2 ± 12% of basal. The extract of Tp C.p. reduced BP to 86.1 ± 11% of basal (p < 0.05 respect to Ntr C.p.) at 180 mg/kg, but increased HR at 90 and 180 mg/kg (until 133.6 ± 10.8% of basal, p < 0.05) and produced death by respiratory paralysis at 320 mg/kg (about 3 g dry leaves/kg). The hypotensive effects, but not the chronotropic ones, were attenuated by pretreatment with reserpine (5 mg/kg). The plant extracts had not diuretic activity by oral administration in conscious rats, nor produced vasodilation of perfused hindquarters arterial bed precontracted with high-[K] or 100 μM phenylephrine. The results suggest that neotropical ambay is more hypotensive than the one from the temperate hilly region. When it reaches plasma, it could produce hypotension (by central blockade of sympathic innervation of vessels) and tachycardia (by central cholinergic inhibition of heart), although it happens at doses higher than the oral ethnotherapeutic (about 340 mg dried leaves/kg).Keywords
This publication has 5 references indexed in Scilit:
- Antioxidant activity of Paraguayan plant extractsFitoterapia, 2003
- Pharmacological effects of Eugenia uniflora (Myrtaceae) aqueous crude extract on rat's heartJournal of Ethnopharmacology, 2002
- A pharmacological study of Cecropia obtusifolia Bertol aqueous extractJournal of Ethnopharmacology, 2001
- Pharmacological basis for the empirical use of Eugenia uniflora L. (Myrtaceae) as antihypertensiveJournal of Ethnopharmacology, 1999
- Hypotensive Activity of Cecropia obtusifoliaJournal of Pharmaceutical Sciences, 1982