Reducing Hypoglycemia in the Real World: A Retrospective Analysis of Predictive Low-Glucose Suspend Technology in an Ambulatory Insulin-Dependent Cohort
Open Access
- 1 September 2019
- journal article
- research article
- Published by Mary Ann Liebert Inc in Diabetes Technology & Therapeutics
- Vol. 21 (9), 478-484
- https://doi.org/10.1089/dia.2019.0190
Abstract
Objective: Analyze real-world usage and impact of a predictive low-glucose suspend (PLGS) insulin delivery system for maintenance of euglycemia and prevention of hypoglycemic events in people with insulin-dependent diabetes. Methods: Retrospective analysis of Tandem Basal-IQ users who uploaded at least 21 days of PLGS usage data between August 31, 2018, and March 14, 2019 (N = 8132). Insulin delivery and sensor-glucose concentrations were analyzed. The times spent below 70 mg/dL, between 70 and 180 mg/dL, and above 180 mg/dL were assessed. Subgroup analyses were conducted to examine matched pre-/postoutcomes with experienced users (n = 1371) and performance over time for a mixed subgroup with >9 weeks of data (n = 3563). Results: The mean age of patients was 32.4 years, 52% were female, 96% had type 1 diabetes, and 4% had type 2 diabetes. Mean duration on PLGS was 65 days. Algorithm introduction led to a 45% median relative risk reduction in sensor time Conclusions: Introduction of PLGS resulted in effective and sustained prevention of hypoglycemia without a significant increase in mean blood glucose and may be considered for people with type 1 diabetes at risk for hypoglycemia.Keywords
This publication has 19 references indexed in Scilit:
- Effect of artificial pancreas systems on glycaemic control in patients with type 1 diabetes: a systematic review and meta-analysis of outpatient randomised controlled trialsThe Lancet Diabetes & Endocrinology, 2017
- Glucose Outcomes with the In-Home Use of a Hybrid Closed-Loop Insulin Delivery System in Adolescents and Adults with Type 1 DiabetesDiabetes Technology & Therapeutics, 2017
- Effectiveness of Automated Insulin Management Features of the MiniMed® 640G Sensor-Augmented Insulin PumpDiabetes Technology & Therapeutics, 2016
- The Potential Cost Implications of Averting Severe Hypoglycemic Events Requiring Hospitalization in High-Risk Adults With Type 1 Diabetes Using Real-Time Continuous Glucose MonitoringJournal of Diabetes Science and Technology, 2016
- Fear of hypoglycemia in adults with type 1 diabetes: impact of therapeutic advances and strategies for prevention - a reviewJournal of Diabetes and its Complications, 2015
- Real-Time Continuous Glucose Monitoring in Type 1 Diabetes: A Qualitative Framework Analysis of Patient NarrativesDiabetes Care, 2014
- Threshold-Based Insulin-Pump Interruption for Reduction of HypoglycemiaNew England Journal of Medicine, 2013
- Effectiveness of Sensor-Augmented Insulin-Pump Therapy in Type 1 DiabetesNew England Journal of Medicine, 2010
- A critical review of the literature on fear of hypoglycemia in diabetes: Implications for diabetes management and patient educationPatient Education and Counseling, 2007
- Estimates of Location Based on Rank TestsThe Annals of Mathematical Statistics, 1963