Minireview on Regulation of Intestinal Calcium Absorption
- 1 January 2008
- journal article
- review article
- Published by S. Karger AG in Digestion
- Vol. 77 (1), 22-34
- https://doi.org/10.1159/000116623
Abstract
An overview of current information on the mechanisms by which intestinal calcium absorption occurs is described in this article. Both paracellular and transcellular pathways are analyzed. Special emphasis focuses on molecules participating in the latter pathway, such as TRPV5 and TRPV6 channels, located in the apical region of the enterocytes, CB(9k) and CB(28k), presumably involved in the cation movement from the apical to the basolateral pole of the cell, and PMCA(1b) and Na(+)/Ca(2+) exchanger, proteins that extrude Ca(2+) from the cells. Current concepts on the relative importance of paracellular and transcellular calcium transport and the vitamin D dependence of each pathway are referred and analyzed showing the contrasting views on this issue. More detailed information is given regarding the stimulatory effect of vitamin D on intestinal Ca(2+) absorption either in animal models or in the human intestine. The possible mechanisms triggered by hormones such as PTH, calcitonin, estrogen, thyroid hormone, glucocorticoids and different nutritional factors on intestinal calcium absorption are also reviewed. Finally, the influence of physiological conditions such as growth, pregnancy, lactation and aging on intestinal calcium absorption are discussed.Keywords
This publication has 101 references indexed in Scilit:
- Effects of gestation and lactation on Vitamin D receptor amounts in goats and sheepDomestic Animal Endocrinology, 2007
- Prolactin-stimulated transepithelial calcium transport in duodenum and Caco-2 monolayer are mediated by the phosphoinositide 3-kinase pathwayAmerican Journal of Physiology-Endocrinology and Metabolism, 2007
- Prolactin is an important regulator of intestinal calcium transportCanadian Journal of Physiology and Pharmacology, 2007
- Intestinal Resistance to 1,25 Dihydroxyvitamin D in Mice Heterozygous for the Vitamin D Receptor Knockout AlleleEndocrinology, 2007
- Calbindin D 9k knockout mice are indistinguishable from wild-type mice in phenotype and serum calcium levelProceedings of the National Academy of Sciences of the United States of America, 2006
- Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transportThe EMBO Journal, 2006
- Mechanisms underlying the effects of inulin-type fructans on calcium absorption in the large intestine of ratsBone, 2005
- Prolactin directly stimulates transcellular active calcium transport in the duodenum of female ratsCanadian Journal of Physiology and Pharmacology, 2001
- Molecular Regulation of the Na+-Ca2+ ExchangerAnnals of the New York Academy of Sciences, 1996
- Effect of Dietary Calcium and Age on Jejunal Calcium Absorption in Humans Studied by Intestinal PerfusionJCI Insight, 1973