Prognostic Significance of Thrombocytosis in Node-negative Colon Cancer
- 1 March 2005
- journal article
- Published by SAGE Publications in Journal of International Medical Research
- Vol. 33 (2), 228-235
- https://doi.org/10.1177/147323000503300211
Abstract
Several clinical studies have shown that thrombocytosis is a poor prognostic factor in some types of cancer, but data about the impact of thrombocytosis on prognosis in patients with colon cancer are very limited. We investigated the prevalence and prognostic effect of pre-operative thrombocytosis, defined as a platelet count > 400 × 109/l, retrospectively in patients with node-negative colon cancer. Out of 198 patients, 24 (12.1%) had thrombocytosis, and its presence correlated with tumour depth and lymphatic invasion. Univariate analysis revealed that disease-free survival and overall survival were shorter in patients with pre-operative thrombocytosis than those without thrombocytosis. On multivariate analysis, thrombocytosis alone retained significance as a poor prognostic factor for both disease-free survival and overall survival. In conclusion, this study shows an association between thrombocytosis and poor survival in patients with node-negative colon cancer. The pre-operative platelet count may help to identify patients with an unfavourable prognosis in this subgroup.Keywords
This publication has 21 references indexed in Scilit:
- Thrombocytosis is Associated With a Significant Increase in the Cancer Specific Death Rate After Radical NephrectomyJournal of Urology, 2002
- Thrombocytosis in Women with Vulvar CarcinomaGynecologic Oncology, 1999
- The Effects of Platelet-Derived Growth Factor and Receptor on Normal and Neoplastic Human Ovarian Surface EpitheliumGynecologic Oncology, 1998
- Prognostic factors in colorectal cancerDiseases of the Colon & Rectum, 1998
- Micrometastases and Survival in Stage II Colorectal CancerNew England Journal of Medicine, 1998
- Vascular endothelial growth factorEuropean Journal of Cancer, 1996
- Clinicopathologic and Prognostic Significance of an Angiogenic Factor, Thymidine Phosphorylase, in Human Colorectal CarcinomaJNCI Journal of the National Cancer Institute, 1996
- Diagnosis of cancer-associated vascular disordersCancer, 1996
- Thrombospondin and transforming growth factor-beta 1 increase expression of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in human MDA-MB-231 breast cancer cellsCancer, 1995
- The expression of thymidine phosphorylase and thrombomodulin in human colorectal carcinomasCancer Letters, 1995