Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality
Open Access
- 1 June 2002
- journal article
- research article
- Published by Oxford University Press (OUP) in Human Reproduction
- Vol. 17 (6), 1591-1596
- https://doi.org/10.1093/humrep/17.6.1591
Abstract
BACKGROUND: The follicular microenvironment is an important determinant of oocyte development. The aim of this study was to examine whether the myo-inositol (MI) content in human follicular fluid (FF) was associated with better oocyte quality. METHODS: A total of 53 patients treated with IVF was recruited to a prospective observational study. FF and serum samples collected were divided into two groups: group A consisted of FF associated with matured and fertilized oocytes, whilst group B was from follicles with immature and unfertilized oocytes. RESULTS: Patient's age, total ampoules of HMG used, days of stimulation, basal levels of FSH, estradiol (E2) levels on the day of HCG, and serum MI content were not significantly different between the two groups. FF volume and its MI content were significantly higher in group A compared with group B (P < 0.05). The levels of MI in FF were positively correlated with the amount of E2 in their corresponding FF samples and also correlated with embryo quality. CONCLUSIONS: We propose that higher concentrations of MI and E2 in human FF appear to play a role in follicular maturity and provide a marker of good quality oocytes.Keywords
This publication has 34 references indexed in Scilit:
- Birth of twins using in vitro matured oocytes and cryopreserved semen from a male with carcinoma of the penisAustralian and New Zealand Journal of Obstetrics and Gynaecology, 2000
- Incorporation of [3H]inositol into phosphoinositides and inositol phosphates by rabbit blastocystsMolecular Reproduction and Development, 1993
- Inositol trisphosphate and calcium signallingNature, 1993
- A correlation of the outcome of clinical in vitro fertilization with the inositol content and embryotrophic properties of human serumJournal of Assisted Reproduction and Genetics, 1992
- myo‐Inositol metabolites as cellular signalsJBIC Journal of Biological Inorganic Chemistry, 1990
- Inositol phosphates and cell signallingNature, 1989
- The cellular functions of myo-inositolBiochemical Society Transactions, 1989
- Development of spare human preimplantation embryos in vitro: An analysis of the correlations among gross morphology, cleavage rates, and development to the blastocystJournal of Assisted Reproduction and Genetics, 1989
- Inositol lipids and cell proliferationBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1987
- FOLLICULAR FLUIDReproduction, 1974