Factors influencing immunologic response to hepatitis B vaccine in adults
Open Access
- 21 June 2016
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 6 (1), 27251
- https://doi.org/10.1038/srep27251
Abstract
Hepatitis B was still a worldwide health problem. This study aimed to conducted a systematic review and meta-analysis to assess a more precise estimation of factors that influence the response to hepatitis B vaccine in adults. Our included studies examined seroprotection rates close to the end of vaccination schedules in healthy adult populations. This meta-analysis including 21053 adults in 37 articles showed that a significantly decreased response to hepatitis B vaccine appeared in adults (age ≥ 40) (RR:1.86, 95% CI:1.55–2.23), male adults (RR:1.40, 95% CI:1.22–1.61), BMI ≥ 25 adults (RR:1.56, 95% CI:1.12–2.17), smoker (RR:1.53, 95% CI:1.21–1.93), and adults with concomitant disease (RR:1.39, 95% CI:1.04–1.86). Meanwhile, we further found a decreased response to hepatitis B vaccine appeared in adults (age ≥ 30) (RR:1.77, 95% CI:1.48–2.10), and adults (age ≥ 60) (RR:1.30, 95% CI:1.01–1.68). However, there were no difference in response to hepatitis B vaccine both in alcoholic (RR:0.90, 95% CI:0.64–1.26) and 0-1-12 vs. 0-1-6 vaccination schedule (RR:1.39, 95% CI:0.41–4.67). Pooling of these studies recommended the sooner the better for adult hepatitis B vaccine strategy. More vaccine doses, supplemental/additional strengthening immunity should be emphasized on the susceptible population of increasing aged, male, BMI ≥ 25, smoking and concomitant disease. The conventional 0-1-6 vaccination schedule could be still worth to be recommended.Keywords
This publication has 60 references indexed in Scilit:
- Efficacy and effectiveness of infant vaccination against chronic hepatitis B in the Gambia Hepatitis Intervention Study (1986–90) and in the nationwide immunisation programBMC Infectious Diseases, 2014
- Infection with hepatitis B and C virus in Europe: a systematic review of prevalence and cost-effectiveness of screeningBMC Infectious Diseases, 2013
- Immunological effects of a 10-μg dose of domestic hepatitis B vaccine in adultsJournal of Zhejiang University-SCIENCE B, 2012
- Effectiveness of HBV Vaccination in Infants and Prediction of HBV Prevalence Trend under New Vaccination Plan: Findings of a Large-Scale InvestigationPLOS ONE, 2012
- Efficacy of an Accelerated Hepatitis B Vaccination Program During PregnancyObstetrics & Gynecology, 2011
- Evaluation of immune response to Hepatitis B vaccine in health care workers at a tertiary care hospital in Pakistan: an observational prospective studyBMC Infectious Diseases, 2007
- Resposta à vacinação contra a hepatite B em alcoolistas sem cirrose hepática clinicamente evidenteArquivos de Gastroenterologia, 2007
- Immunogenicity and safety assessment of the Cuban recombinant hepatitis B vaccine in healthy adultsBiologicals, 2007
- Hepatitis B vaccination in women healthcare workers: A seroepidemiological surveyEuropean Journal of Epidemiology, 2007
- Differential genetic determination of immune responsiveness to hepatitis B surface antigen and to hepatitis A virus: a vaccination study in twinsThe Lancet, 2002