Apolipoprotein A-I as a Marker of Angiographically Assessed Coronary-Artery Disease
- 18 August 1983
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 309 (7), 385-389
- https://doi.org/10.1056/nejm198308183090701
Abstract
This study was designed to determine whether the plasma level of apolipoprotein A-I is a better discriminator of angiographically documented coronary-artery disease than the level of high-density–lipoprotein (HDL) cholesterol in male subjects. The level of plasma apolipoprotein A-I in 83 patients with coronary-artery disease was 96.7±4.2 mg per deciliter (mean ±S.E.M.), which was significantly lower (P<0.0001) than the level in 25 patients without coronary-artery disease (146.9±2.1 mg per deciliter). The levels of HDL cholesterol were also lower (P<0.0001) in patients with coronary-artery disease (31.9±1.5 mg per deciliter) than in those without it (45.9±2.3 mg per deciliter). A stepwise discriminant analysis, however, indicated the superiority of apolipoprotein A-I over HDL cholesterol in detecting coronary-artery disease. Furthermore, a linear discriminant analysis suggested that although HDL cholesterol by itself was a discriminator of coronary-artery disease, it did not provide a substantial increase in discriminatory value over that provided by apolipoprotein A-I; in contrast, apolipoprotein A-I levels added discriminatory value to the information obtained by measuring HDL cholesterol alone.Keywords
This publication has 20 references indexed in Scilit:
- Multivariate analyses of serum apolipoproteins and risk factors in relation to acute myocardial infarction.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1981
- Plasma apolipoprotein B and VLDL-, LDL-, and HDL- cholesterol as risk factors in the development of coronary artery disease in male patients examined by angiographyAtherosclerosis, 1981
- Association of risk factor variables and coronary artery disease documented with angiography.Circulation, 1981
- Relationship between apolipoproteins and chemical components of lipoproteins in survivors of myocardial infarctionAtherosclerosis, 1980
- High Density Lipoproteins and AtherosclerosisAnnual Review of Medicine, 1980
- Serum high density lipoprotein in diabetic patientsDiabetologia, 1977
- Cholesterol content and sterol synthesis in human skin fibroblasts and rat aortic smooth muscle cells exposed to lipoprotein-depleted serum and high density apolipoprotein/phospholipid mixturesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1976
- SERUM-HIGH-DENSITY-LIPOPROTEIN AND ATHEROSCLEROTIC HEART-DISEASEThe Lancet, 1976
- A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart AssociationCirculation, 1975
- PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASEThe Lancet, 1975