Electronic nicotine delivery systems: a research agenda
- 17 March 2011
- journal article
- editorial
- Published by BMJ in Tobacco Control
- Vol. 20 (3), 243-248
- https://doi.org/10.1136/tc.2010.042168
Abstract
Electronic nicotine delivery systems (ENDS, also called electronic cigarettes or e-cigarettes) are marketed to deliver nicotine and sometimes other substances by inhalation. Some tobacco smokers report that they used ENDS as a smoking cessation aid. Whether sold as tobacco products or drug delivery devices, these products need to be regulated, and thus far, across countries and states, there has been a wide range of regulatory responses ranging from no regulation to complete bans. The empirical basis for these regulatory decisions is uncertain, and more research on ENDS must be conducted in order to ensure that the decisions of regulators, health care providers and consumers are based on science. However, there is a dearth of scientific research on these products, including safety, abuse liability and efficacy for smoking cessation. The authors, who cover a broad range of scientific expertise, from basic science to public health, suggest research priorities for non-clinical, clinical and public health studies. They conclude that the first priority is to characterize the safety profile of these products, including in long-term users. If these products are demonstrated to be safe, their efficacy as smoking cessation aids should then be tested in appropriately designed trials. Until these studies are conducted, continued marketing constitutes an uncontrolled experiment and the primary outcome measure, poorly assessed, is user health. Potentially, this research effort, contributing to the safety and efficacy of new smoking cessation devices and to the withdrawal of dangerous products, could save many lives.This publication has 37 references indexed in Scilit:
- Nanostructured and Spiky Gold Shell Growth on Magnetic Particles for SERS ApplicationsNanomaterials, 2020
- Novel Nicotine Delivery Systems and Public Health: The Rise of the “E-Cigarette”American Journal of Public Health, 2010
- A Clinical Laboratory Model for Evaluating the Acute Effects of Electronic “Cigarettes”: Nicotine Delivery Profile and Cardiovascular and Subjective EffectsCancer Epidemiology, Biomarkers & Prevention, 2010
- Electronic cigarettes: a survey of usersBMC Public Health, 2010
- Abuse Liability Assessment of Tobacco Products Including Potential Reduced Exposure ProductsCancer Epidemiology, Biomarkers & Prevention, 2009
- Clinical Trials Methods for Evaluation of Potential Reduced Exposure ProductsCancer Epidemiology, Biomarkers & Prevention, 2009
- Risk management and post-marketing surveillance for the abuse of medications acting on the central nervous system: Expert Panel ReportDrug and Alcohol Dependence, 2009
- Presence of the Carcinogen N′-Nitrosonornicotine in the Urine of Some Users of Oral Nicotine Replacement Therapy ProductsCancer Research, 2009
- Debunking the claim that abstinence is usually healthier for smokers than switching to a low-risk alternative, and other observations about anti-tobacco-harm-reduction argumentsHarm Reduction Journal, 2009
- Evidence for endogenous formation of N′-nitrosonornicotine in some long-term nicotine patch usersNicotine & Tobacco Research, 2009