Interferon-induced guanylate-binding proteins: Guardians of host defense in health and disease
Open Access
- 28 February 2019
- journal article
- review article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 216 (3), 482-500
- https://doi.org/10.1084/jem.20182031
Abstract
Guanylate-binding proteins (GBPs) have recently emerged as central orchestrators of immunity to infection, inflammation, and neoplastic diseases. Within numerous host cell types, these IFN-induced GTPases assemble into large nanomachines that execute distinct host defense activities against a wide variety of microbial pathogens. In addition, GBPs customize inflammasome responses to bacterial infection and sepsis, where they act as critical rheostats to amplify innate immunity and regulate tissue damage. Similar functions are becoming evident for metabolic inflammatory syndromes and cancer, further underscoring the importance of GBPs within infectious as well as altered homeostatic settings. A better understanding of the basic biology of these IFN-induced GTPases could thus benefit clinical approaches to a wide spectrum of important human diseases.Keywords
Funding Information
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI068041-12, R01AI108834-05)
- Howard Hughes Medical Institute
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