Total Synthesis of (±)-Jiadifenin, a Non-peptidyl Neurotrophic Modulator
- 16 October 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (44), 14358-14359
- https://doi.org/10.1021/ja045939p
Abstract
We report the first total synthesis of jiadifenin (1), the establishment of a modality for its biological evaluation, and the discovery of apparently more potent neurotrophic activity in fully synthetic compound 17, an intermediate en route to 1.Keywords
This publication has 12 references indexed in Scilit:
- New seco-Prezizaane-Type Sesquiterpenes, Jiadifenin with Neurotrophic Activity and 1,2-Dehydroneomajucin from Illicium jiadifengpiJournal of Natural Products, 2002
- The Total Synthesis of (±)-Merrilactone AJournal of the American Chemical Society, 2002
- Cyclohexenonic Long-Chain Fatty Alcohols as Neuronal Growth StimulatorsMolecules, 2000
- A Fully Synthetic Route to the Neurotrophic Illicinones: Syntheses of Tricycloillicinone and Bicycloillicinone AldehydeJournal of the American Chemical Society, 2000
- A Fully Synthetic Route to the Neurotrophic Illicinones by Sequential Aromatic Claisen RearrangementsJournal of the American Chemical Society, 1998
- PHARMACOLOGY OF NEUROTROPHIC FACTORSAnnual Review of Pharmacology and Toxicology, 1997
- Sesquiterpene lactones from the pericarps of Illicium majus; 2-oxy derivatives of neomajucin and 3,4-dehydroxyneomajucin.CHEMICAL & PHARMACEUTICAL BULLETIN, 1990
- Synthesis and asymmetric reactivity of enantiomerically pure cyclopentadienylmetal complexes derived from the chiral poolOrganometallics, 1988
- Reaktionen des (+)‐Thujons und (−)‐Isothujons mit FormaldehydEuropean Journal of Inorganic Chemistry, 1981
- Synthese von 18‐Carboxy‐steroiden. Über Steroide, 146. MitteilungHelvetica Chimica Acta, 1957