Modulation of proline-rich protein biosynthesis in rat parotid glands by sorghums with high tannin levels.
Open Access
- 1 July 1983
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 80 (13), 3948-3952
- https://doi.org/10.1073/pnas.80.13.3948
Abstract
Feeding of sorghum with a high level of tannin to rats caused changes in gene expression in parotid glands similar to isoproterenol treatment. Within 3 days the parotid glands were enlarged .apprx. 3-fold, and a series of proline-rich proteins were increased .apprx. 12-fold. Unlike isoproterenol treatment, no changes were observed in the submandibular glands, and a 220,000 MW glycoprotein in parotid glands was not induced. Amino acid analyses, electrophoretic patterns and cell-free translations of mRNA all confirmed that the proline-rich proteins induced by feeding high-tannin sorghum were identical to those induced by isoproterenol treatment. Binding curves for proline-rich proteins to tannins showed affinities 10-fold greater than bovine serum albumin and tannins.This publication has 26 references indexed in Scilit:
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