Inflammation and Immune Response in COPD: Where Do We Stand?
Open Access
- 15 July 2013
- journal article
- review article
- Published by Hindawi Limited in Mediators of Inflammation
- Vol. 2013, 1-9
- https://doi.org/10.1155/2013/413735
Abstract
Increasing evidence indicates that chronic inflammatory and immune responses play key roles in the development and progression of COPD. Recent data provide evidence for a role in the NLRP3 inflammasome in the airway inflammation observed in COPD. Cigarette smoke activates innate immune cells by triggering pattern recognition receptors (PRRs) to release “danger signal”. These signals act as ligands to Toll-like receptors (TLRs), triggering the production of cytokines and inducing innate inflammation. In smokers who develop COPD there appears to be a specific pattern of inflammation in the airways and parenchyma as a result of both innate and adaptive immune responses, with the predominance of CD8+ and CD4+ cells, and in the more severe disease, with the presence of lymphoid follicles containing B lymphocytes and T cells. Furthermore, viral and bacterial infections interfere with the chronic inflammation seen in stable COPD and exacerbations via pathogen-associated molecular patterns (PAMPs). Finally, autoimmunity is another novel aspect that may play a critical role in the pathogenesis of COPD. This review is un update of the currently discussed roles of inflammatory and immune responses in the pathogenesis of COPD.Keywords
This publication has 104 references indexed in Scilit:
- IL-18 Induces Emphysema and Airway and Vascular Remodeling via IFN-γ, IL-17A, and IL-13American Journal of Respiratory and Critical Care Medicine, 2012
- Significance of the microbiome in obstructive lung diseaseThorax, 2012
- Topographical Continuity of Bacterial Populations in the Healthy Human Respiratory TractAmerican Journal of Respiratory and Critical Care Medicine, 2011
- Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease ExacerbationAmerican Journal of Respiratory and Critical Care Medicine, 2011
- Autophagy in immunity and inflammationNature, 2011
- Human rhinovirus proteinase 2A induces TH1 and TH2 immunity in patients with chronic obstructive pulmonary diseaseJournal of Allergy and Clinical Immunology, 2010
- Chronic Cigarette Smoke Exposure Generates Pathogenic T Cells Capable of Driving COPD-like Disease in Rag2−/− MiceAmerican Journal of Respiratory and Critical Care Medicine, 2010
- Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary diseaseTrends in Pharmacological Sciences, 2009
- T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patientsClinical and Experimental Immunology, 2009
- The Foxp3+ regulatory T cell: a jack of all trades, master of regulationNature Immunology, 2008