Immunogenicity of a Psoralen-Inactivated Dengue Virus Type 1 Vaccine Candidate in Mice
- 1 February 2010
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 17 (2), 304-306
- https://doi.org/10.1128/cvi.00353-09
Abstract
We evaluated a novel psoralen-inactivated dengue virus type 1 (DENV-1) vaccine candidate in Mus musculus mice. Mice received intradermal alum or 5 to 10 ng of psoralen-inactivated virus. Anti-DENV-1 neutralizing antibody was detectable in 10/11 mice receiving a 10-ng dose at 90 days. Psoralen-inactivated DENV-1 is immunogenic in mice.Keywords
This publication has 10 references indexed in Scilit:
- Quantification of Viral Inactivation by Photochemical Treatment with Amotosalen and UV A Light, Using a Novel Polymerase Chain Reaction Inhibition Method with PreamplificationThe Journal of Infectious Diseases, 2006
- A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccinesNature Medicine, 2006
- Photochemical treatment of plasma with amotosalen and long‐wavelength ultraviolet light inactivates pathogens while retaining coagulation functionTransfusion, 2006
- The Role of Photochemical Treatment With Amotosalen and UV-A Light in the Prevention of Transfusion-Transmitted Cytomegalovirus InfectionsTransfusion Medicine Reviews, 2006
- Photochemical inactivation of viruses and bacteria in platelet concentrates by use of a novel psoralen and long‐wavelength ultraviolet lightTransfusion, 1997
- Review of accidents caused by incomplete inactivation of viruses.1993
- Psoralen preparation of antigenically intact noninfectious rotavirus particlesJournal of Virological Methods, 1992
- An overview of the inactivation of FMDV and the implications when residual virus is present in vaccines.1991
- Psoralen Photochemistry and Nucleic Acid StructureJournal of Investigative Dermatology, 1981
- Photochemical Inactivation of DNA and RNA Viruses by Psoralen DerivativesJournal of General Virology, 1978