Translational Systems Biology of Inflammation: Potential Applications to Personalized Medicine
- 29 September 2010
- journal article
- Published by Informa UK Limited in Personalized Medicine
- Vol. 7 (5), 549-559
- https://doi.org/10.2217/pme.10.45
Abstract
A central goal of industrialized nations is to provide personalized, pre-emptive and predictive medicine, while maintaining healthcare costs at a minimum. To do so, we must confront and gain an understanding of inflammation, a complex, nonlinear process central to many diseases that affect both industrialized and developing nations. Herein, we describe the work aimed at creating a rational, engineering-oriented and evidence-based synthesis of inflammation geared towards rapid clinical application. This comprehensive approach, which we call ‘Translational Systems Biology’, to date has been utilized for in silico studies of sepsis, trauma/hemorrhage/traumatic brain injury, acute liver failure and wound healing. This framework has now allowed us to suggest how to modulate acute inflammation in a rational and individually optimized fashion using engineering principles applied to a biohybrid device. We suggest that we are on the cusp of fulfilling the promise of in silico modeling for personalized medicine for...Keywords
Funding Information
- National Institutes of Health Grants (R01-GM-67240, P50-GM-53789, R33-HL-089082, R01-HL080926, R01-AI080799, R01-DC-008290, R01-HL-76157)
- National Institute on Disability and Rehabilitation Research Grant (H133E070024)
- National Science Foundation (0830-370-V601, IIS-0938393)
- NNIH-NIDDK (UO1-DK072146-05)
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