H3K9 methyltransferase G9a and the related molecule GLP
Top Cited Papers
- 15 April 2011
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 25 (8), 781-788
- https://doi.org/10.1101/gad.2027411
Abstract
The discovery of Suv39h1, the first SET domain-containing histone lysine methyltransferase (HKMT), was reported in 2000. Since then, research on histone methylation has progressed rapidly. Among the identified HKMTs in mammals, G9a and GLP are the primary enzymes for mono- and dimethylation at Lys 9 of histone H3 (H3K9me1 and H3K9me2), and exist predominantly as a G9a–GLP heteromeric complex that appears to be a functional H3K9 methyltransferase in vivo. Recently, many important studies have reported that G9a and GLP play critical roles in various biological processes. The physiological relevance of G9a/GLP-mediated epigenetic gene regulation is discussed.Keywords
This publication has 88 references indexed in Scilit:
- Epigenetic Regulation of Learning and Memory by Drosophila EHMT/G9aPLoS Biology, 2011
- Arabidopsis Histone Lysine MethyltransferasesAdvances in Botanical Research, 2010
- Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1DEpigenetics & Chromatin, 2010
- G9a selectively represses a class of late-replicating genes at the nuclear peripheryProceedings of the National Academy of Sciences of the United States of America, 2009
- UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modificationsEpigenetics, 2009
- Protein lysine methyltransferase G9a acts on non-histone targetsNature Chemical Biology, 2008
- Identification of ZNF200 as a novel binding partner of histone H3 methyltransferase G9aGenes to Cells, 2007
- Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian ChromatinMolecular Cell, 2003
- Suv39h-Mediated Histone H3 Lysine 9 Methylation Directs DNA Methylation to Major Satellite Repeats at Pericentric HeterochromatinCurrent Biology, 2003
- SET domain proteins modulate chromatin domains in eu- and heterochromatinCellular and Molecular Life Sciences, 1998