The fundamental link between pneumococcal carriage and disease
Top Cited Papers
- 1 July 2012
- journal article
- review article
- Published by Taylor & Francis Ltd in Expert Review of Vaccines
- Vol. 11 (7), 841-855
- https://doi.org/10.1586/erv.12.53
Abstract
Streptococcus pneumoniae (pneumococcus) is a major cause of worldwide mortality and morbidity, and to a large extent is vaccine-preventable. Nasopharyngeal carriage of pneumococcus precedes disease and is the source of pneumococcal spread between people. The use of vaccine effect on carriage as part of the vaccine licensure and post-vaccine introduction evaluation could facilitate and expand the licensure of new, life-saving pneumococcal vaccines and enable a comprehensive estimate of population effects after vaccine introduction. The authors provide a review of the evidence supporting pneumococcal carriage at the individual level as an immediate and necessary precursor to pneumococcal disease. Based on such a causal link between carriage and disease, the authors emphasize the role of information on pneumococcal carriage in vaccine trials and in public health decision-making.Keywords
This publication has 99 references indexed in Scilit:
- Use of a Rapid Test of Pneumococcal Colonization Density to Diagnose Pneumococcal PneumoniaClinical Infectious Diseases, 2011
- Impact of More Than a Decade of Pneumococcal Conjugate Vaccine Use on Carriage and Invasive Potential in Native American CommunitiesThe Journal of Infectious Diseases, 2011
- Next generation pneumococcal vaccinesCurrent Opinion in Immunology, 2011
- Nasopharyngeal Carriage of Individual Streptococcus pneumoniae Serotypes During Pediatric Pneumonia as a Means to Estimate Serotype Disease PotentialThe Pediatric Infectious Disease Journal, 2011
- Nasopharyngeal Carriage of Streptococcus pneumoniae in Gambian Children who Participated in a 9-valent Pneumococcal Conjugate Vaccine Trial and in Their Younger SiblingsThe Pediatric Infectious Disease Journal, 2009
- Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimatesThe Lancet, 2009
- Identification of a Pneumococcal Glycosidase That Modifies O-Linked GlycansInfection and Immunity, 2009
- Evaluating a surrogate endpoint at three levels, with application to vaccine developmentStatistics in Medicine, 2008
- Capsule Enhances Pneumococcal Colonization by Limiting Mucus-Mediated ClearanceInfection and Immunity, 2007
- Streptococcus pneumoniae colonisation: the key to pneumococcal diseaseThe Lancet Infectious Diseases, 2004