Serum Folate and Risk of Fatal Coronary Heart Disease
- 26 June 1996
- journal article
- research article
- Published by American Medical Association (AMA)
- Vol. 275 (24), 1893-6
- https://doi.org/10.1001/jama.1996.03530480035037
Abstract
Objective. —To assess the relationship between serum folate level and the risk of fatal coronary heart disease (CHD) among men and women. Design. —Retrospective cohort study with serum folate levels measured from September 1970 to December 1972, with follow-up through 1985. Setting. —Participants in the Nutrition Canada Survey. Participants. —A total of 5056 Canadian men and women aged 35 to 79 years with no history of self-reported CHD. Main Outcome Measure. —Fifteen-year CHD mortality. Results. —A total of 165 CHD deaths were observed. We found a statistically significant association between serum folate level and risk of fatal CHD, with rate ratios for individuals in the lowest serum folate level category (13.6 nmol/L [6 ng/mL]) of 1.69 (95% confidence interval, 1.10-2.61). Conclusions. —These data indicate that low serum folate levels are associated with an increased risk of fatal CHD. (JAMA. 1996;275:1893-1896)Keywords
This publication has 12 references indexed in Scilit:
- The treatment of coronary heart disease: an update. Part 1: An overview of the risk factors for cardiovascular disease.Current Medical Research and Opinion, 2001
- Folic acid fortification of grain: an economic analysis.American Journal of Public Health, 1995
- Can Lowering Homocysteine Levels Reduce Cardiovascular Risk?New England Journal of Medicine, 1995
- Micronutrients and Cancer: Time for Action?JNCI Journal of the National Cancer Institute, 1993
- Forty-five-month follow-up of extracranial carotid arterial disease for new coronary events in elderly patientsCoronary Artery Disease, 1992
- Ultrasonographically assessed carotid morphology and the risk of coronary heart disease.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1991
- Major Risk Factors for Cardiovascular Disease Mortality in Adults: Results from the Nutrition Canada Survey CohortInternational Journal of Epidemiology, 1988
- Homocysteinemia due to folate deficiencyMetabolism, 1987
- SERUM CHOLESTEROL, BLOOD PRESSURE, AND MORTALITY: IMPLICATIONS FROM A COHORT OF 361 662 MENThe Lancet, 1986
- A generalized iterative record linkage computer system for use in medical follow-up studiesComputers and Biomedical Research, 1981