Computational methods for the design of effective therapies against drug resistant HIV strains
Open Access
- 6 September 2005
- journal article
- review article
- Published by Oxford University Press (OUP) in Bioinformatics
- Vol. 21 (21), 3943-3950
- https://doi.org/10.1093/bioinformatics/bti654
Abstract
Summary: The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data. Contact:niko@math.berkeley.eduThis publication has 24 references indexed in Scilit:
- Learning Multiple Evolutionary Pathways from Cross-Sectional DataJournal of Computational Biology, 2005
- Estimating HIV Evolutionary Pathways and the Genetic Barrier to Drug ResistanceThe Journal of Infectious Diseases, 2005
- Mtreemix: a software package for learning and using mixture models of mutagenetic treesBioinformatics, 2005
- HIV Drug ResistanceThe New England Journal of Medicine, 2004
- Improved Coreceptor Usage Prediction and GenotypicMonitoring of R5-to-X4 Transition by Motif Analysis of HumanImmunodeficiency Virus Type 1 env V3 LoopSequencesJournal of Virology, 2003
- Tenofovir Resistance and ResensitizationAntimicrobial Agents and Chemotherapy, 2003
- Enhanced Prediction of Lopinavir Resistance from Genotype by Use of Artificial Neural NetworksThe Journal of Infectious Diseases, 2003
- Non‐parametric methods to predict HIV drug susceptibility phenotype from genotypeStatistics in Medicine, 2003
- A New Perspective on V3 Phenotype PredictionAIDS Research and Human Retroviruses, 2003
- Methods for Investigation of the Relationship between Drug‐Susceptibility Phenotype and Human Immunodeficiency Virus Type 1 Genotype with Applications to AIDS Clinical Trials Group 333The Journal of Infectious Diseases, 2000