How the Dorsal gradient works: Insights from postgenome technologies
Open Access
- 23 December 2008
- journal article
- review article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 105 (51), 20072-20076
- https://doi.org/10.1073/pnas.0806476105
Abstract
Gradients of extracellular signaling molecules and transcription factors are used in a variety of developmental processes, including the patterning of the Drosophila embryo, the establishment of diverse neuronal cell types in the vertebrate neural tube, and the anterior–posterior patterning of vertebrate limbs. Here, we discuss how a gradient of the maternal transcription factor Dorsal produces complex patterns of gene expression across the dorsal–ventral (DV) axis of the early Drosophila embryo. The identification of 60–70 Dorsal target genes, along with the characterization of ≈35 associated regulatory DNAs, suggests that there are at least six different regulatory codes driving diverse DV expression profiles.Keywords
This publication has 50 references indexed in Scilit:
- Evolution of genes and genomes on the Drosophila phylogenyNature, 2007
- Enhancer Responses to Similarly Distributed Antagonistic Gradients in DevelopmentPLoS Computational Biology, 2007
- Whole-genome ChIP–chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryoGenes & Development, 2007
- Comprehensive identification of Drosophila dorsal–ventral patterning genes using a whole-genome tiling arrayProceedings of the National Academy of Sciences of the United States of America, 2006
- The TAGteam DNA motif controls the timing ofDrosophilapre-blastoderm transcriptionDevelopment, 2006
- Dorsal-Ventral Pattern of Delta Trafficking Is Established by a Snail-Tom-Neuralized PathwayDevelopmental Cell, 2006
- Genomic Regulatory Networks and Animal DevelopmentDevelopmental Cell, 2005
- Drosophila Rhomboid-1 Defines a Family of Putative Intramembrane Serine ProteasesCell, 2001
- DNA bending and orientation-dependent function of YY1 in the c-fos promoter.Genes & Development, 1993
- Molecular analysis of a cellular decision during embryonic development of Drosophila melanogaster: epidermogenesis or neurogenesisEuropean Journal of Biochemistry, 1990