Primitive squamous cell carcinoma of the breast (SCCB): case report of an uncommon variant of metaplastic carcinoma
- 1 January 2017
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Il Giornale di Chirurgia - Journal of the Italian Association of Hospital Surgeons
- Vol. 38 (3), 139-142
- https://doi.org/10.11138/gchir/2017.38.3.139
Abstract
Metaplastic carcinoma of the breast includes a heterogeneous group of neoplasms characterized by admixture of adenocarcinoma with area of squamous, chondroid and osseous differentiation. If the tumor shows pure squamous differentiation, it is designated as squamous carcinoma. SCCB accounts for less than 1% of all invasive breast carcinoma. It can present as cystic lesions and simulate a breast abscess. A 75-year old woman was visited at our General Surgery Unit for a palpable lump, about 5 cm in size, at the lower inner quadrant of right breast. Mammography revealed 3cm oval opacity with micro calcifications and US appearance as isoechogenic lump with lesion solid-cystic appearance; cytology deposes for cystic inflammatory lesion(C2) to be monitored. A subsequent ultrasound check one year later confirmed an increase of volume, so micro histology sampling was made with suspect malignancy(B4). After biopsy, the patient underwent excision of cyst. Final histological examination showed SCCB with diffuse positivity for Cytokeratin 34beta-E12 and p63; negative reactions to ER and PR; monoclonal antibody Ki67 > 40%; HER2/neu with score 2+ and FISH examination negative. Subsequently, the patient underwent radical Madden mastectomy which confirmed the histological diagnosis and the negativity of the lymph nodes. In literature, prognosis and therapy are still discussed; SCCB has shown very little responsiveness to common chemotherapy. A quadrantectomy or a radical mastectomy with lymph node dissection must be considered the best treatment for this rare neoplasia.Keywords
This publication has 10 references indexed in Scilit:
- Primary squamous cell carcinoma of breast with ipsilateral axillary lymph node metastasis: An unusual caseInternational Journal of Surgery Case Reports, 2011
- Squamous cell carcinoma of the breast in the form of an intracystic tumorBreast Cancer, 2007
- A case of HER-2(+) squamous cell breast carcinoma: An unusual presentation of an unusual clinical entityEuropean Journal of Surgical Oncology, 2006
- Pure primary squamous cell carcinoma of the breast: A rare presentation and clinicopathologic comparison with usual ductal carcinoma of the breastPathology - Research and Practice, 2006
- A pure primary squamous cell breast carcinoma presenting as a breast abscess: case report and review of literature.2004
- Squamous cell carcinoma of the breast: clinico-pathologic implications and outcomeEuropean Journal of Surgical Oncology, 2003
- Primary Squamous Cell Carcinoma of the Breast Presenting as a Breast AbscessThe American Surgeon, 1999
- Primary squamous cell carcinoma of the breast: Sensitivity to cisplatinum-based chemotherapyJournal of Surgical Oncology, 1995
- Pure squamous carcinoma of the breast. Report of a case diagnosed by aspiration cytology.1989
- Primary squamous cell carcinoma of the breastCancer, 1981