Significance of green granules in neutrophils and monocytes
- 29 December 2017
- journal article
- case report
- Published by Informa UK Limited in Baylor University Medical Center Proceedings
- Vol. 31 (1), 94-96
- https://doi.org/10.1080/08998280.2017.1391045
Abstract
Intracytoplasmic green granules in neutrophils have been the subject of conjecture and discussion. Sometimes nicknamed “death cells,” these granules are often associated with severe liver disease and have been said to predict acute bad outcomes in severely ill patients. Some recommend that the laboratory community report these granules to treating clinicians as an indication of poor prognosis. We report two patients presenting with secondary liver disease who were found to have blue-green neutrophilic inclusions on the peripheral blood smear. One patient died, while the other patient recovered. We propose that this morphologic finding is likely transient and is related to liver disease and that recovery is possible. Additionally, prognosis in intensive care units continues to be determined by a number of variables, such as age, comorbidities, and severity of illness.Keywords
This publication has 10 references indexed in Scilit:
- Quick SOFA Scores Predict Mortality in Adult Emergency Department Patients With and Without Suspected InfectionAnnals of Emergency Medicine, 2017
- Green Neutrophilic Inclusions are Frequently Associated With Liver Injury and May Portend Short-Term Mortality in Critically Ill PatientsLaboratory Medicine, 2016
- Relationship Between ICU Length of Stay and Long-Term Mortality for Elderly ICU Survivors*Critical Care Medicine, 2016
- Green neutrophil and monocyte inclusions – time to acknowledge and reportBritish Journal of Haematology, 2015
- Green neutrophilic inclusions could be a sign of impending death!Blood, 2014
- Green neutrophilic inclusions in liver diseaseJournal of Clinical Pathology, 2009
- You say lipofuscin, we say ceroid: Defining autofluorescent storage materialNeurobiology of Aging, 2006
- LipofuscinThe International Journal of Biochemistry & Cell Biology, 2003
- Lipofuscin: mechanisms of age-related accumulation and influence on cell function12 1Guest Editor: Rajindar S. Sohal 2This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal.Free Radical Biology & Medicine, 2002
- Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of careCritical Care Medicine, 2001