Treatment and survival of patients with occult breast cancer with axillary lymph node metastasis: A nationwide retrospective study
- 26 May 2014
- journal article
- research article
- Published by Wiley in Journal of Surgical Oncology
- Vol. 110 (3), 270-274
- https://doi.org/10.1002/jso.23644
Abstract
Occult breast cancer (OBC) accounts for 0.3–1.0% of all breast cancers and is a rare presentation of the disease. The present retrospective study examined the overall survival and prognostic factors associated with OBC in Korea. The study included 142 OBC patients identified from the Korean Breast Cancer Society cancer registry from January 1990 to December2009. All patients had pathologically positive axillary lymph nodes (N1–N3) and pathologically and radiologically negative in-breast lesions (T0/Tx) based on a retrospective review of the database. No statistically significant differences in overall survival were observed between patients undergoing axillary lymph node dissection (ALND) only (80.8%), breast conserving surgery (BCS) with ALND (98.0%), and mastectomy with ALND (92.5%) with P-value of 0.061. Nodal status was a significant prognostic factor (P = 0.004) on univariate analysis. When compared with T1 patients group, T0/TxN1 patients showed better survival than T1N1 patients (hazard ratio [HR] 0.253; 95% confidence interval, 0.104–0.618; P = 0.003), but T0/TxN2, T0/TxN3 patients showed similar survival to T1N2, T1N3 patients. OBC patients treated with ALND only showed comparable outcomes to those undergoing ALND combined with BCS or mastectomy. Nodal status may be an independent predictor of poor outcome in OBC patients. J. Surg. Oncol. 2014 110:270–274.Keywords
Funding Information
- Korea Breast Cancer Foundation (2012)
This publication has 28 references indexed in Scilit:
- Treatment outcomes and unfavorable prognostic factors in patients with occult breast cancerEuropean Journal of Surgical Oncology, 2012
- Immunohistochemically defined subtypes and outcome in occult breast carcinoma with axillary presentationBreast Cancer Research and Treatment, 2011
- Breast Radiotherapy for Occult Breast Cancer with Axillary Nodal Metastases — Does it Reduce the Local Recurrence Rate and Increase Overall Survival?Clinical Oncology, 2011
- Population‐based analysis of occult primary breast cancer with axillary lymph node metastasisCancer, 2010
- Clinical Benefits of Mastectomy on Treatment of Occult Breast Carcinoma Presenting Axillary MetastasesThe Breast Journal, 2010
- Prognosis of Occult Breast Carcinoma Presenting as Isolated Axillary Nodal MetastasisOncology, 2006
- Clinical experience with axillary presentation breast cancerBreast Cancer Research and Treatment, 2004
- Feasibility of Breast Preservation in the Treatment of Occult Primary Carcinoma Presenting With Axillary MetastasesAnnals of Surgical Oncology, 2001
- Occult primary adenocarcinoma with axillary metastasesThe American Journal of Surgery, 1986
- Surgical Significance of Isolated Axillary AdenopathyAnnals of Surgery, 1957