Prediagnostic Circulating Parathyroid Hormone Concentration and Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort
- 1 May 2011
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Epidemiology, Biomarkers & Prevention
- Vol. 20 (5), 767-778
- https://doi.org/10.1158/1055-9965.epi-10-1212
Abstract
Background: Parathyroid hormone (PTH) has been proposed to play a promoting role in carcinogenesis. However, no epidemiologic studies have yet directly investigated its role in colorectal cancer (CRC). Methods: A case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort was conducted with 1,214 incident, sporadic CRC cases matched to 1,214 controls. Circulating prediagnostic PTH and 25-hydroxy vitamin D [25(OH)D] concentrations were measured by enzyme-linked immunosorbent assays. Detailed dietary and lifestyle questionnaire data were collected at baseline. Multivariable conditional logistic regression was used to estimate the incidence rate ratio (RR) with 95% confidence intervals (95% CI) for the association between circulating PTH and CRC risk. Results: In multivariate analyses [including adjustment for 25(OH)D concentration] with a priori defined cutoff points, high levels of serum PTH (≥65 ng/L) compared with medium PTH levels of 30–65 ng/L were associated with increased CRC risk (RR = 1.41, 95% CI: 1.03–1.93). In analyses by sex, the CRC risk was 1.77 (95% CI: 1.14–2.75) and 1.15 (95% CI: 0.73–1.84) in men and women, respectively (Pheterogeneity = 0.01). In subgroup analyses by anatomical subsite, the risk for colon cancer was RR = 1.56, 95% CI: 1.03–2.34, and for rectal cancer RR = 1.20, 95% CI: 0.72–2.01 (Pheterogeneity = 0.21). Effect modification by various risk factors was examined. Conclusions: The results of this study suggest that high serum PTH levels may be associated with incident, sporadic CRC in Western European populations, and in particular among men. Impact: To our knowledge, this is the first study on PTH and CRC. The role of PTH in carcinogenesis needs to be further investigated. Cancer Epidemiol Biomarkers Prev; 20(5); 767–78. ©2011 AACR.Keywords
This publication has 58 references indexed in Scilit:
- Relationship of vitamin D and parathyroid hormone with obesity and body composition in African AmericansClinical Endocrinology, 2010
- Serum levels of IGF‐I, IGFBP‐3 and colorectal cancer risk: results from the EPIC cohort, plus a meta‐analysis of prospective studiesInternational Journal of Cancer, 2010
- The Relation of Serum Parathyroid Hormone and Serum Calcium to Serum Levels of Prostate-Specific Antigen: A Population-Based StudyCancer Epidemiology, Biomarkers & Prevention, 2009
- Vitamin D Receptor and Calcium Sensing Receptor Polymorphisms and the Risk of Colorectal Cancer in European PopulationsCancer Epidemiology, Biomarkers & Prevention, 2009
- Relation of body fat indexes to vitamin D status and deficiency among obese adolescentsThe American Journal of Clinical Nutrition, 2009
- The association of adiposity with parathyroid hormone in healthy older adultsEndocrine, 2009
- What Do Case-Control Studies Estimate? Survey of Methods and Assumptions in Published Case-Control ResearchAmerican Journal of Epidemiology, 2008
- Parathyroid hormone and parathyroid hormone-related peptide, and their receptorsBiochemical and Biophysical Research Communications, 2005
- Parathyroid hormone may be a cancer promoter – an explanation for the decrease in cancer risk associated with ultraviolet light, calcium, and vitamin DMedical Hypotheses, 2000
- Familial hyperparathyroidism in association with colonic carcinomaCancer, 1987