Cerebral Ventricular Enlargement in Chronic Schizophrenia
- 1 January 1980
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 37 (1), 11-3
- https://doi.org/10.1001/archpsyc.1980.01780140013001
Abstract
Response to neuroleptic drug treatment in ten chronic schizophrenic patients with enlarged cerebral ventricles was compared with ten similar patients with normal ventricles. The groups were closely matched for age, age at onset of illness, years of illness and hospitalization, drug dosage, and plasma neuroleptic concentration as measured by radioreceptor assay. Response was significantly worse in the patients with enlarged ventricles. This finding supports the notion that ventricular enlargement is clinically relevant in patients with chronic schizophrenia and that patients with this abnormality may have a biologically different illness than similar patients without it.Keywords
This publication has 2 references indexed in Scilit:
- A simple and sensitive radioreceptor assay for antischizophrenic drugs in bloodNature, 1977
- A LONG‐TERM FOLLOW‐UP STUDY OF SCHIZOPHRENIA: PSYCHIATRIC COURSE OF ILLNESS AND PROGNOSISActa Psychiatrica Scandinavica, 1975