The oxidation of propane was studied in a jet-stirred flow reactor in the temperature range 900-1200 K at pressure s extending from 1 to 10 atrn for a wide range of fuel-oxygen equivalence ratios (0.15 to 4.0), A comput er program has been developed to model the experimental data using a chemical kinetic reaction mechan ism. A direct method to determine the first orde r sensitivities of the mole fraction of each species with respect to the rate constants was used to develop the kinetic scheme. The present chemical kinetic reaction mechanism is able to reproduce our experimental results, although some discrepanci es are observed for the minor products, particularly for acetylene. The validation of the present mechanism is extended to higher temperatures, in order to describe the oxidation of propane in shock tubes. The experimental ignition delays obtained behind reflected shock waves, by various authors, are compared with the pred ictions of the model. Good agreement is found in the temperature range 1200–1700 K.