Role of the Preoptic-Anterior Hypothalamus in Thermoregulation and Fever
Open Access
- 1 October 2000
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 31 (Supplement), S157-S161
- https://doi.org/10.1086/317521
Abstract
Lesion and thermal stimulation studies suggest that temperature regulation is controlled by a hierarchy of neural structures. Effector areas for specific thermoregulatory responses are located throughout the brain stem and spinal cord. The preoptic region, in and near the rostral hypothalamus, acts as a coordinating center and strongly influences each of the lower effector areas. The preoptic area contains neurons that are sensitive to subtle changes in hypothalamic or core temperature. Preoptic thermosensitive neurons also receive a wealth of somatosensory input from skin and spinal thermoreceptors. In this way, preoptic neurons compare and integrate central and peripheral thermal information. As a result of this sensory integration and its control over lower effector areas, the preoptic region elicits the thermoregulatory responses that are the most appropriate for both internal and environmental thermal conditions. Thermosensitive preoptic neurons are also affected by endogenous substances, such as pyrogens. By reducing the activity of warm-sensitive neurons and increasing the activity of cold-sensitive neurons, pyrogens cause fever, a state in which all thermoregulatory responses have elevated set-point temperatures.This publication has 30 references indexed in Scilit:
- Hypothalamic Neurons Regulating Body TemperaturePublished by American Geophysical Union (AGU) ,1996
- Neurophysiological Aspects of ThermoregulationPublished by Springer Science and Business Media LLC ,1989
- ACTIVATION OF HEAT LOSS MECHANISMS BY LOCAL HEATING OF THE BRAINJournal of Neurophysiology, 1938
- HYPOTHALAMUS AND TEMPERATURE CONTROLArchives of Neurology & Psychiatry, 1933
- Observations on the Localization in the Brain-stem of Mechanisms Controlling Body TemperatureThe American Journal of the Medical Sciences, 1933
- The central and the reflex mechanism of pantingJournal Of Physiology-London, 1933
- Pharmakologische und physiologische Studien über die SchweißzentrenNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1929
- Die Wirkung unmittelbarer Erwärmung und Abkühlung der Wärmezentra auf die KörpertemperaturNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1912
- EFFECT OF INCREASED TEMPERATURE OF THE CAROTID BLOODAmerican Journal of Physiology-Legacy Content, 1911
- Die Beziehungen des Gehirns zur Körperwärme und zum FieberPflügers Archiv - European Journal of Physiology, 1885