Controlled Assembly of Biodegradable Plasmonic Nanoclusters for Near-Infrared Imaging and Therapeutic Applications
- 7 April 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Nano
- Vol. 4 (4), 2178-2184
- https://doi.org/10.1021/nn9015746
Abstract
Metal nanoparticles with surface plasmon resonance (SPR) in the near-infrared region (NIR) are of great interest for imaging and therapy. Presently, gold nanoparticles with NIR absorbance are typically larger than 50 nm, above the threshold size of ∼5 nm required for efficient renal clearance. As these nanoparticles are not biodegradable, concerns about long-term toxicity have restricted their translation into the clinic. Here, we address this problem by developing a flexible platform for the kinetically controlled assembly of sub-5 nm ligand-coated gold particles to produce metal/polymer biodegradable nanoclusters smaller than 100 nm with strong NIR absorbance for multimodal application. A key novel feature of the proposed synthesis is the use of weakly adsorbing biodegradable polymers that allows tight control of nanocluster size and, in addition, results in nanoclusters with unprecedented metal loadings and thus optical functionality. Over time, the biodegradable polymer stabilizer degrades under physiological conditions that leads to disassembly of the nanoclusters into sub-5 nm primary gold particles which are favorable for efficient body clearance. This synthesis of polymer/inorganic nanoclusters combines the imaging contrast and therapeutic capabilities afforded by the NIR-active nanoparticle assembly with the biodegradability of a polymer stabilizer.This publication has 39 references indexed in Scilit:
- Small Multifunctional Nanoclusters (Nanoroses) for Targeted Cellular Imaging and TherapyACS Nano, 2009
- Particle Size, Surface Coating, and PEGylation Influence the Biodistribution of Quantum Dots in Living MiceSmall, 2009
- Remote Optical Switch for Localized and Selective Control of Gene InterferenceNano Letters, 2009
- Biodegradable Plasmon Resonant NanoshellsAdvanced Materials, 2008
- Biosensing with plasmonic nanosensorsNature Materials, 2008
- Gold Nanocages for Biomedical ApplicationsAdvanced Materials, 2007
- Renal clearance of quantum dotsNature Biotechnology, 2007
- Biodegradable nanoparticles for cytosolic delivery of therapeuticsAdvanced Drug Delivery Reviews, 2007
- Immuno Gold Nanocages with Tailored Optical Properties for Targeted Photothermal Destruction of Cancer CellsNano Letters, 2007
- Bifunctional Gold Nanoshells with a Superparamagnetic Iron Oxide−Silica Core Suitable for Both MR Imaging and Photothermal TherapyThe Journal of Physical Chemistry C, 2007