Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation
Open Access
- 31 January 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Musculoskeletal Disorders
- Vol. 14 (1), 49
- https://doi.org/10.1186/1471-2474-14-49
Abstract
Background Serum preptin levels among subjects with different bone mineral densities (BMD) were measured and investigated to determine the correlation between BMD and bone-metabolic markers. Methods Approximately 52 elderly male patients with osteoporosis, 50 elderly men with osteopaenia, and 31 age-matched normal bone mass controls participated in the study. The serum preptin levels and bone metabolic markers were measured by enzyme-linked immunosorbent assay. The relationships between preptin levels, BMD, and metabolic parameters were also assessed. Results The serum preptin level was the lowest in the osteoporosis group and positively correlated with BMD. All the bone formation markers in the osteoporosis and osteopaenia groups were significantly reduced compared with those in the normal group. Serum preptin level was positively correlated with all the bone formation markers, whereas no correlation was observed with the bone resorption marker TRACP-5b. Conclusions Serum preptin levels are decreased in osteoporosis and osteopaenia patients and positively correlated with BMD. Therefore, preptin is involved in the pathogenesis of osteoporosis, probably through bone formation rather than bone resorption.This publication has 26 references indexed in Scilit:
- Salvianolic Acid B Prevents Bone Loss in Prednisone-Treated Rats through Stimulation of Osteogenesis and Bone Marrow AngiogenesisPLOS ONE, 2012
- Teriparatide increases bone mineral density in a man with osteoporosis pseudogliomaJournal of Bone and Mineral Research, 2011
- Connective tissue growth factor is a downstream mediator for preptin-induced proliferation and differentiation in human osteoblastsAmino Acids, 2009
- Circulating preptin levels in normal, impaired glucose tolerance, and type 2 diabetic subjectsAnnals of Medicine, 2009
- Building bone to reverse osteoporosis and repair fracturesJCI Insight, 2008
- Mechanisms of Anabolic Therapies for OsteoporosisThe New England Journal of Medicine, 2007
- Preptin, another peptide product of the pancreatic β-cell, is osteogenic in vitro and in vivoAmerican Journal of Physiology-Endocrinology and Metabolism, 2007
- Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet β-cells and enhances insulin secretionBiochemical Journal, 2001
- A neuro (endo)crine regulation of bone remodelingBioEssays, 2000
- Osteoporosis in Elderly Men and Women: Effects of Dietary Calcium, Physical Activity, and Body Mass IndexJournal of Bone and Mineral Research, 2000