Asthma is associated with Increased mortality in individuals with sickle cell anemia
- 1 August 2007
- journal article
- Published by Ferrata Storti Foundation (Haematologica) in Haematologica
- Vol. 92 (8), 1115-1118
- https://doi.org/10.3324/haematol.11213
Abstract
An analysis of a prospective cohort of individuals with sickle cell anemia (SCA), enrolled from birth through adulthood, was conducted to determine if asthma is a risk factor for death in SCA. All-cause mortality was determined for participants after adjusting for known risk factors for death in SCA. The study included 1,963 individuals who were followed for 18,495 patient-years. After controlling for established risk factors, individuals with SCA and asthma had a more than two-fold higher risk of mortality (hazard ratio 2.36, 95% CI 1.21 to 4.62, p=0.01). To summarize, asthma is a risk factor for death in SCA.Keywords
This publication has 18 references indexed in Scilit:
- Asthma is associated with acute chest syndrome and pain in children with sickle cell anemiaBlood, 2006
- Asthma in children with sickle cell disease and its association with acute chest syndromeThorax, 2005
- Asthma and acute chest in sickle‐cell diseasePediatric Pulmonology, 2004
- Prevalence of Childhood Asthma and Associated Morbidity in Los Angeles County: Impacts of Race/Ethnicity and IncomeJournal of Asthma, 2003
- Prevalence of asthma and asthma-like symptoms in inner-city elementary schoolchildrenPediatric Pulmonology, 2002
- Prevalence and consequences of asthma and wheezing in African-American and White adolescentsJournal of Adolescent Health, 2001
- Links between pediatric and adult asthmaJournal of Allergy and Clinical Immunology, 2001
- Prevalence of asthma and other allergic diseases in an adolescent population: association with gender and raceAnnals of Allergy, Asthma & Immunology, 2001
- Mortality In Sickle Cell Disease -- Life Expectancy and Risk Factors for Early DeathNew England Journal of Medicine, 1994
- Prophylaxis with Oral Penicillin in Children with Sickle Cell AnemiaNew England Journal of Medicine, 1986