Role of pancreatic stellate cells in chemoresistance in pancreatic cancer
Open Access
- 9 April 2014
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Physiology
- Vol. 5, 141
- https://doi.org/10.3389/fphys.2014.00141
Abstract
Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over the last decade there has been intensive research into the role of the pro-fibrogenic pancreatic stellate cells (PSCs) and their interaction with pancreatic cancer cells. As a result of the significant alterations in the tumor microenvironment following activation of PSCs, tumor progression, and chemoresistance is enhanced. This review will discuss how PSCs contribute to chemoresistance in pancreatic cancer.Keywords
This publication has 94 references indexed in Scilit:
- Alteration of pancreatic cancer cell functions by tumor-stromal cell interactionFrontiers in Physiology, 2013
- Causes, consequences, and remedies for growth-induced solid stress in murine and human tumorsProceedings of the National Academy of Sciences of the United States of America, 2012
- Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal AdenocarcinomaCancer Cell, 2012
- Inhibition of renin–angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabineBritish Journal of Cancer, 2010
- Pancreatic CancerNew England Journal of Medicine, 2010
- Epidemiology of pancreatic cancer: an overviewNature Reviews Gastroenterology & Hepatology, 2009
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic CancerScience, 2009
- Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant MetastasisCancer Cell, 2009
- Targeting multidrug resistance in cancerNature Reviews Drug Discovery, 2006
- Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylationThe EMBO Journal, 2001