Parasitic Protozoa and Interactions with the Host Intestinal Microbiota
Open Access
- 1 August 2017
- journal article
- review article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 85 (8)
- https://doi.org/10.1128/iai.00101-17
Abstract
Parasitic protozoan infections represent a major health burden in the developing world and contribute significantly to morbidity and mortality. These infections are often associated with considerable variability in clinical presentation. An emerging body of work suggests that the intestinal microbiota may help to explain some of these differences in disease expression. The objective of this minireview is to synthesize recent progress in this rapidly advancing field. Studies of humans and animals and in vitro studies of the contribution of the intestinal microbiota to infectious disease are discussed. We hope to provide an understanding of the human-protozoal pathogen-microbiome interaction and to speculate on how that might be leveraged for treatment.Keywords
Funding Information
- HHS | NIH | National Institute of Allergy and Infectious Diseases (AI-26649)
- Bill and Melinda Gates Foundation (OPP1173478)
This publication has 91 references indexed in Scilit:
- Diversity, stability and resilience of the human gut microbiotaNature, 2012
- Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000The Lancet, 2012
- Structure, function and diversity of the healthy human microbiomeNature, 2012
- The Lifestyle of the Segmented Filamentous Bacterium: A Non-Culturable Gut-Associated Immunostimulating Microbe Inferred by Whole-Genome SequencingDNA Research, 2011
- Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic miceProceedings of the National Academy of Sciences of the United States of America, 2011
- Giardia duodenalis: The double-edged sword of immune responses in giardiasisExperimental Parasitology, 2010
- Systemic gut microbial modulation of bile acid metabolism in host tissue compartmentsProceedings of the National Academy of Sciences of the United States of America, 2010
- Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitisProceedings of the National Academy of Sciences of the United States of America, 2010
- Induction of Intestinal Th17 Cells by Segmented Filamentous BacteriaCell, 2009
- Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patientsProceedings of the National Academy of Sciences of the United States of America, 2008