Thrombospondins in the heart: potential functions in cardiac remodeling
Open Access
- 2 October 2009
- journal article
- Published by Wiley in Journal of Cell Communication and Signaling
- Vol. 3 (3-4), 201-213
- https://doi.org/10.1007/s12079-009-0070-6
Abstract
Cardiac remodeling after myocardial injury involves inflammation, angiogenesis, left ventricular hypertrophy and matrix remodeling. Thrombospondins (TSPs) belong to the group of matricellular proteins, which are non-structural extracellular matrix proteins that modulate cell–matrix interactions and cell function in injured tissues or tumors. They interact with different matrix and membrane-bound proteins due to their diverse functional domains. That the expression of TSPs strongly increases during cardiac stress or injury indicates an important role for them during cardiac remodeling. Recently, the protective properties of TSP expression against heart failure have been acknowledged. The current review will focus on the biological role of TSPs in the ischemic and hypertensive heart, and will describe the functional consequences of TSP polymorphisms in cardiac disease.Keywords
This publication has 108 references indexed in Scilit:
- Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retinaAmerican Journal of Physiology-Heart and Circulatory Physiology, 2009
- Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stressMatrix Biology, 2009
- Differential Interactions of Thrombospondin-1, -2, and -4 with CD47 and Effects on cGMP Signaling and Ischemic Injury ResponsesPublished by Elsevier BV ,2009
- Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarctionThe Journal of Experimental Medicine, 2008
- CD47Arteriosclerosis, Thrombosis, and Vascular Biology, 2008
- Periostin is essential for cardiac healingafter acute myocardial infarctionThe Journal of Experimental Medicine, 2008
- Thrombospondins: from structure to therapeuticsCellular and Molecular Life Sciences, 2008
- Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failureGenes & Development, 2006
- Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heartGenes & Development, 2006
- Myofibroblasts and mechano-regulation of connective tissue remodellingNature Reviews Molecular Cell Biology, 2002