Retrospective Characterization of a Vaccine-Derived Poliovirus Type 1 Isolate from Sewage in Greece
- 1 November 2007
- journal article
- Published by American Society for Microbiology in Applied and Environmental Microbiology
- Vol. 73 (21), 6697-6704
- https://doi.org/10.1128/aem.00535-07
Abstract
Retrospective molecular and phenotypic characterization of a vaccine-derived poliovirus (VDPV) type 1 isolate (7/b/97) isolated from sewage in Athens, Greece, in 1997 is reported. VP1 sequencing of this isolate revealed 1.87% divergence from the VP1 region of reference strain Sabin 1, while further genomic characterization of isolate 7/b/97 revealed a recombination event in the nonstructural part of the genome between a vaccine strain and a nonvaccine strain probably belonging to Enterovirus species C. Amino acid substitutions commonly found in previous studies were identified in the capsid coding region of the isolate, while most of the attenuation and temperature sensitivity determinants were reverted. The ultimate source of isolate 7/b/97 is unknown. The recovery of such a highly divergent derivative of a vaccine strain emphasizes the need for urgent implementation of environmental surveillance as a supportive procedure in the polio surveillance system even in countries with high rates of OPV coverage in order to prevent cases or even outbreaks of poliomyelitis that otherwise would be inevitable.Keywords
This publication has 51 references indexed in Scilit:
- Antigenic Evolution of Vaccine-Derived Polioviruses: Changes in Individual Epitopes and Relative Stability of the Overall Immunological PropertiesJournal of Virology, 2006
- Long-Term Excretion of Vaccine-Derived Poliovirus by a Healthy ChildJournal of Virology, 2004
- Serial Recombination during Circulation of Type 1 Wild-Vaccine Recombinant Polioviruses in ChinaJournal of Virology, 2003
- Complete Genomic Sequencing Shows that Polioviruses and Members of Human Enterovirus Species C Are Closely Related in the Noncapsid Coding RegionJournal of Virology, 2003
- Circulation of Endemic Type 2 Vaccine-Derived Poliovirus in Egypt from 1983 to 1993Journal of Virology, 2003
- Nucleotide variation in Sabin type 2 poliovirus from an immunodeficient patient with poliomyelitisJournal of General Virology, 2003
- Complexes of Poliovirus Serotypes with Their Common Cellular Receptor, CD155Journal of Virology, 2003
- Long-Term Circulation of Vaccine-Derived Poliovirus That Causes Paralytic DiseaseJournal of Virology, 2002
- Shedding of Virulent Poliovirus Revertants during Immunization with Oral Poliovirus Vaccine after Prior Immunization with Inactivated Polio VaccineThe Journal of Infectious Diseases, 1993
- Intertypic genomic rearrangements of poliovirus strains in vaccineesVirology, 1988