Analysis of Clinical Characteristics of Low-Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Cohort Study of 51 LAMN Patients
Open Access
- 6 January 2020
- journal article
- research article
- Published by Informa UK Limited in Journal of Investigative Surgery
- Vol. 34 (7), 721-727
- https://doi.org/10.1080/08941939.2019.1695986
Abstract
Introduction: Low-grade appendiceal mucinous neoplasm (LAMN) is a rare disorder. There is no consensus on the prognosis and management of LAMN. Materials and methods: We reviewed 51 consecutive patients with LAMN from 2013 to 2018. We divided our patients into two groups. The first is patients with an intact appendix. The second group comprises patients with the potential to develop a malignant condition. Comparisons of serum tumor markers between two groups were performed. Survival curves were estimated. Univariate and multivariate Cox proportional hazards were computed for 46 patients with median follow-up of 2.7 years. Results: Comparison of patients in two groups revealed significant differences in the mean level and abnormal ratio of CA125 (p < 0.001, p < 0.001), CA19-9 (p = 0.04, p = 0.04), and CEA (p = 0.001, p = 0.02). Eight patients had relapsed by the last follow-up in the second group. Patients with normal CEA had significantly longer disease-free survival (DFS) time than those with abnormal CEA (p = 0.04). CA19-9 exhibited a significant association with DFS (HR = 5.72, p = 0.02) in the Univariate Cox proportional hazards. Discussion: The prognosis of LAMN is related to serum tumor markers, the surgical procedure and the pathology.Keywords
This publication has 23 references indexed in Scilit:
- Management and prognosis of low-grade appendiceal mucinous neoplasms: A clinicopathologic analysis of 50 casesEuropean Journal of Surgical Oncology, 2018
- Clinical Surveillance After Macroscopically Complete Surgery for Low-Grade Appendiceal Mucinous Neoplasms (LAMN) with or Without Limited Peritoneal Spread: Long-Term Results in a Prospective SeriesAnnals of Surgical Oncology, 2017
- The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritoneiHistopathology, 2017
- Computed Tomography Follow-Up Assessment of Patients with Low-Grade Appendiceal Mucinous Neoplasms: Evaluation of Risk for Pseudomyxoma PeritoneiAnnals of Surgical Oncology, 2017
- A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal NeoplasiaThe American Journal of Surgical Pathology, 2016
- Significance of Proximal Margin Involvement in Low-Grade Appendiceal Mucinous NeoplasmsArchives of Pathology & Laboratory Medicine, 2015
- Mucinous epithelial neoplasms of the appendix and pseudomyxoma peritoneiLaboratory Investigation, 2015
- Epithelial Appendiceal NeoplasmsThe Cancer Journal, 2009
- Management of an unexpected appendiceal neoplasmBritish Journal of Surgery, 2006
- Right hemicolectomy does not confer a survival advantage in patients with mucinous carcinoma of the appendix and peritoneal seedingBritish Journal of Surgery, 2004