Marrow Transplantation for Nonmalignant Disorders

Abstract

IN 1978 Parkman et al.¹ reported the complete correction of the Wiskott–Aldrich syndrome in two patients by allogeneic marrow transplantation after preparation with antihuman thymocyte serum and total-body irradiation. The article and the accompanying editorial² indicated the potential of marrow transplantation for the correction of a wide variety of nonmalignant diseases. Five years and many reports later, it is apparent that much progress has been made but that many problems remain.The modern era of human bone-marrow transplantation began at the end of the 1960s, when techniques of human histocompatibility typing made it possible to select HLA-identical siblings as donors. . . .