A case study of temporal lobe development in familial schizophrenia
Open Access
- 1 January 1996
- journal article
- case report
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 26 (1), 191-195
- https://doi.org/10.1017/s0033291700033821
Abstract
Case studies of patients with familial schizophrenia may help to define the pathophysiology of this illness and indicate potential candidate genes for genetic linkage studies. In this regard, the clinical, radiological and pathological assessments of a 39-year-old affected man from a pedigree with familial schizophrenia are presented. Brain imaging with CT indicated moderate cortical atrophy, particularly of the temporal lobes. Neuropathological examination revealed granular ependymitis, indicating possible past ventricular pathology. Granular ependymitis was reported to occur in genetic developmental disorders with neuronal migration abnormalities. In the present case, heterotopic clusters of neurons were visualized in the entorhinal cortex, suggesting that temporal lobe development was not entirely normal. This case study suggests that genetic factors could be investigated further as one possible aetiology of certain neurodevelopmental abnormalities observed in schizophrenia.This publication has 26 references indexed in Scilit:
- Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factorNature, 1994
- Medial temporal lobe structures in schizophrenia: relationship of size to duration of illnessSchizophrenia Research, 1994
- Reduction of cortical volume in schizophrenia on magnetic resonance imagingPsychological Medicine, 1993
- Novel Triplet Repeat Containing Genes in Human Brain: Cloning, Expression, and Length PolymorphismsGenomics, 1993
- Loss of sylvian fissure asymmetry in schizophrenia: A quantitative post mortem studySchizophrenia Research, 1992
- Qualitative and quantitative assessment of pre-alpha-cell clusters in the entorhinal cortex of schizophrenics. A neurodevelopmental model of schizophrenia?Schizophrenia Research, 1991
- Limbic pathology in schizophrenia: The entorhinal region—a morphometric studyBiological Psychiatry, 1988
- Prenatal developmental disturbances in the limbic allocortex in schizophrenicsJournal of Neural Transmission, 1986
- Developmental dyslexia: Four consecutive patients with cortical anomaliesAnnals of Neurology, 1985
- “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinicianJournal of Psychiatric Research, 1975