Does physical inactivity cause nonalcoholic fatty liver disease?
Open Access
- 1 December 2011
- journal article
- review article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 111 (6), 1828-1835
- https://doi.org/10.1152/japplphysiol.00384.2011
Abstract
While physical activity represents a key element in the prevention and management of many chronic diseases, we and others believe that physical inactivity is a primary cause of obesity and associated metabolic disorders. Unfortunately, accumulating evidence suggests that we have engineered physical activity out of our normal daily living activity. One such consequence of our sedentary and excessive lifestyle is nonalcoholic fatty liver disease (NAFLD), which is now considered the most common cause of chronic liver disease in Westernized societies. In this review, we will present evidence that physical inactivity, low aerobic fitness, and overnutrition, either separately or in combination, are an underlying cause of NAFLD.Keywords
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