Adipokines, Insulin Resistance and Hyperandrogenemia in Obese Patients with Polycystic Ovary Syndrome: Cross-Sectional Correlations and the Effects of Weight Loss
- 1 January 2012
- journal article
- Published by S. Karger AG in Obesity Facts
- Vol. 5 (4), 495-504
- https://doi.org/10.1159/000341579
Abstract
Objective: To assess the effects of weight loss on serum adipokine levels in polycystic ovary syndrome (PCOS). Methods: We determined serum leptin, adiponectin, resistin, and visfatin levels in 60 overweight/obese women with PCOS and 48 BMI-matched female volunteers. Measurements were repeated after 24 weeks of treatment with orlistat 120 mg 3 times per day along with an energy-restricted diet. Results: At baseline, serum visfatin concentration was higher in patients with PCOS than in controls (p = 0.036); serum levels of leptin, adiponectin, and resistin did not differ between the two groups. After 24 weeks, a significant reduction in BMI and waist circumference was observed in both patients with PCOS and controls (p Conclusions: Leptin, adiponectin, and resistin do not appear to play major pathogenetic roles in overweight/obese patients with PCOS. In contrast, visfatin emerges as a potentially important mediator of the endocrine abnormalities of these patients. However, serum visfatin levels are not substantially affected by weight loss.Keywords
This publication has 30 references indexed in Scilit:
- Plasma visfatin level in women with polycystic ovary syndromeGynecological Endocrinology, 2010
- Effect of metformin on serum visfatin levels in patients with polycystic ovary syndromeFertility and Sterility, 2010
- An update on the pathogenesis, inflammation, and metabolism in hirsutism and polycystic ovary syndromeGynecological Endocrinology, 2009
- Effects of protein versus simple sugar intake on weight loss in polycystic ovary syndrome (according to the National Institutes of Health criteria)Fertility and Sterility, 2009
- Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysisHuman Reproduction Update, 2009
- Anti-Müllerian hormone levels reflect severity of PCOS but are negatively influenced by obesity: relationship with increased luteinizing hormone levelsAmerican Journal of Physiology-Endocrinology and Metabolism, 2009
- Adipocytokines and the Metabolic Complications of ObesityJournal of Clinical Endocrinology & Metabolism, 2008
- A randomized trial of the effects of two types of short-term hypocaloric diets on weight loss in women with polycystic ovary syndromeFertility and Sterility, 2004
- Serum Leptin Levels in Women with Polycystic Ovary Syndrome: The Role of Insulin Resistance/ HyperinsulinemiaJournal of Clinical Endocrinology & Metabolism, 1997
- Leptin Concentrations in the Polycystic Ovary SyndromeJournal of Clinical Endocrinology & Metabolism, 1997